Le CCM peut toutefois prendre un aspect kystique, ou de plaques. Enfin, la localisation du CCM peut aussi varier. Diagnostic Le diagnostic du CCM est avant tout histologique et immuno-histochimique. Les cellules tumorales sont aussi positives pour les granules neuroendocrines synaptophysine et chromogranine.
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Overview Merkel cell carcinoma MCC is also called neuroendocrine carcinoma of the skin. The cancer usually presents as a single reddish or purple lump on a part of the skin that is often exposed to sunlight, such as the face, neck, or arms. Although skin cancer is the most common type of cancer in the United States, Merkel cell carcinoma is considered rare.
The majority of people diagnosed with this type of cancer are white and over the age of Merkel cell carcinoma is different from other types of skin cancer because of the type of cells involved. Merkel cell carcinoma starts in the Merkel cells. By comparison, basal cell carcinoma , the most common type of skin cancer, occurs in the basal cells of the skin.
Melanoma develops from skin cells known as melanocytes. Stages of Merkel cell carcinoma After receiving a cancer diagnosis, your doctor will run tests to find out if the cancer has spread to other parts of your body. This is referred to as staging. Staging is important for determining what types of treatment are needed.
In general, a higher number stage means the further a cancer has spread. The lump is typically: red or violet in color firm to the touch fast-growing painless The nodule can form anywhere on the body, but most often appears on areas regularly exposed to sunlight, such as the: face neck arms If the cancer spreads to the lymph nodes, the nodes may grow large enough to be seen as lumps under the skin.
What causes Merkel cell carcinoma? Merkel cell carcinoma originates in cells at the bottom of the epidermis, known as the Merkel cells. The epidermis is the outer layer of the skin. Merkel cells are connected to nerve endings that give us our sense of touch. Merkel cell carcinoma occurs when something goes wrong within these cells and causes them to grow uncontrollably.
Other known risk factors include: being older than 50 years old excessive sun exposure using tanning beds having light-colored skin having a compromised immune system, including people with HIV or chronic leukemia , and people taking immunosuppressive drugs Diagnosing Merkel cell carcinoma Merkel cell carcinoma may be detected during a physical exam by your doctor or dermatologist.
Your doctor will check for lumps, lesions, or irregularly shaped moles. They may also ask you for a detailed medical history, history of sun exposure, and if anyone in your family has had skin cancer. If your doctor finds anything abnormal, they may perform a skin biopsy to check for cancer. During a skin biopsy, a tiny amount of the lump is removed and viewed under a microscope. If the biopsy is positive for Merkel cell carcinoma, your doctor will run additional tests to determine the stage and extent of the cancer.
These tests may include: a sentinel lymph node biopsy, to find out if the cancer has spread to your lymph nodes.
Célula de Merkel
Carcinoma de células de Merkel